protac linker 10 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7701	Boc-NH-PEG3	PROTAC Linker 10	Others , PROTAC Linker
	Boc-NH-PEG3 (PROTAC Linker 10) is a PEG derivative containing a hydroxyl group and Boc-protected amino group, and is a PROTAC linker.		Others , PROTAC Linker
T14413	Azido-PEG10-alcohol		Others , PROTAC Linker
	Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].		Others , PROTAC Linker
T17694	Br-C10-methyl ester		Others , PROTAC Linker
	Br-C10-methyl ester, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a lin...		Others , PROTAC Linker
T17881	(S,R,S)-AHPC-C10-NH2	VH032-C10-NH2	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising the (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications.		Others , Ligand for E3 Ligase
T18661	(S,R,S)-AHPC-C10-NH2 dihydrochloride	VH032-C10-NH2 dihydrochloride,VH032-linker 10,VH032 amide-alkylC10-amine	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker[1].		Others , Ligand for E3 Ligase
T13999	(10-BRomodecyl)phosphonic acid		Others
	(10-BRomodecyl)phosphonic acid is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].		Others
T17901	CIAP1 Ligand-Linker Conjugates 10	E3 ligase Ligand-Linker Conjugates 47	Others
	cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROT...		Others
T15120	Diethyl 10-bromodecylphosphonate		Others
	Diethyl 10-bromodecylphosphonate is an alkyl-based PROTAC linker utilized for the synthesis of PROTACs[1].		Others
T18515	Palbociclib-propargyl	PROTAC CDK6 ligand 1	Others
	Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].		Others
T14000	[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid		Others
	The compound [10-(diethoxy-phosphoryl)-decyl]-phosphonic acid is a suitable alkyl chain-based PROTAC linker for the synthesis of PROTACs [1].		Others
T16583	Propargyl-PEG1-acid		Others
	Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and ...		Others
T18682	SJFδ		Others
	SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].		Others
T15834	M-PEG10-alcohol	Decaethylene glycol monomethyl ether	Others
	m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PE...		Others
T17904	Pomalidomide-PEG1-C2-N3	E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13	Others
	Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are common...		Others
T71919	Boc-10-Aminodecanoic acid
	Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino g...
T18601	Desmethyl-QCA276	PROTAC BRD4-binding moiety 4	Others
	Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].		Others
T18680	SD-36		Others
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their ...		Others
T41146	ND1-YL2	ND1-YL2
	ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a link...
T83856	AP-1
	AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as...